Abstract
Summary
(1) Twelve dogs receiving barbital, phenobarbital or Presidon daily for six months to one year were observed for neurological disturbances and alterations in the histology of the viscera, blood and brain. (2) Dogs receiving barbital for one year developed a mild ataxia. These dogs and one receiving phenobarbital for one year had small splenic tumors at autopsy. All other post mortem findings were negative with respect to histologic changes in the viscera and blood. Small structures similar to amyloid bodies seen in man were found in the brain stem and cortex of all dogs treated one year, but not in dogs treated six months. These structures could not be correlated with neurological changes in behavior, nor is their significance known.
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