Abstract
Summary and Conclusion
(1) Experiments have been described comparing the effects of adrenocortical extract, desoxycorticosterone and cortisone on blood levels and urinary excretion of ascorbic acid in dogs and in rats. 2. The data show that all of the above substances reduce the urinary excretion of ascorbic acid. In this connection, cortisone is more effective in rats, while desoxycorticosterone is the most effective in dogs. 3. All the compounds caused increased plasma and cell ascorbic acid in dogs and in rats. 4. Inconsistent patterns were seen in the influence of the adreno-steroids on tissue distribution of ascorbic acid. In many instances, the adreno-steroids reduced markedly the tissue content of ascorbic acid. 5. Adrenocortical extract and cortisone were more effective than desoxycorticosterone on storage of ascorbic acid at the adrenal gland.
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