Abstract
Summary
It has been shown that the isolated guinea pig gall bladder-common duct preparation is suitable for the evaluation of antispasmodic and antihistaminic activity. The log dose-response curve is linear over a wide range. The drugs studied are rated in the following order in counteracting or preventing acetylcholine spasm: Atropine, Phenergan, diphenhydramine, Ambodryl, Then-fadil, C-5581-H, chlorocyclizine, chloropro-phenpyridamine and Anthallan.
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