Abstract
Summary
Benzaldehyde thiosemicarba-zone prevents multiplication of vaccinia virus in chick embryonic tissues when present in a concentration of one μg per ml of medium. Substitutions in the para position of the benzene nucleus or in the 4-position of the thiosemicarbazone portion of the molecule reduce virostatic activity. 2. When fed in the diet, benzaldehyde thiosemicarbazone produces a marked degree of protection of mice inoculated intracerebrally with vaccinia virus. Derivatives with substitutions in the para position of the benzene nucleus or in the 4-position of the thiosemicarbazone portion of the molecule produce little or no protection against vaccinia infection in mice. 3. The thiosemicarbazones do not appear to inactivate vaccinia virus as the result of prolonged contactin vitro.
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