The Lability of Thiamine in Certain Purified Rations. ∗

Abstract

Summary

The “nervous syndrome” condition produced in rats after 10 weeks or longer on a low protein, niacin-free regimen has been shown to respond to thiamine supplementation. Complete protection from the convulsions was affected when sulfasuxidine was added to the ration. Analyses of the rations for thiamine showed that as much as 70% of the vitamin was destroyed in the non-sulfasuxidine ration, while very little destruction occurred in the ration containing the drug. The addition of 0.2% dl-phenylalanine did not increase the thiamine requirement.