Beta-Glucuronidase in Leukocytes,Plasma,and Urine of Patients with Nephrosis Undergoing Treatment with ACTH. ∗

Abstract

Summary and Conclusions

1. Observations on the effects of activation of the adrenal cortex by ACTH on the B-glucuronidase activity of plasma, leukocytes, and urine are reported. 2. ACTH administration evokes a marked rise in plasma and white cell glucuronidase activity. Plasma glucuronidase activity correlates well with the total corticosteroid level elicited by the ACTH in that it increases during administration and decreases following administration although the day-to-day parallel is variable. 3. Urinary glucuronidase activity fails to indicate significant correlations either with plasma and white cell glucuronidase or with the corticosteroids.