Abstract
Summary
When mice were infected by the intranasal route with large doses of influenza virus and immune serum was introduced into the lungs 1 hour later, the animals died even though neither the amount of infectious virus in the lungs at the time the serum was given nor the amount subsequently produced was as great as the corresponding amounts found in the lungs of mice that had been infected with small doses of virus and that were protected when immune serum was given 24 hours later. The findings suggest that a large amount of influenza virus introduced directly into the mouse lung may, by itself, be sufficient to kill the animal without any subsequent multiplication of the agent.
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