Progressive Growth of C3H Mouse Lymphosarcoma in CF 1 Mice Treated with Cortisone Acetate

Abstract

Discussion and Summary

The data show that the resistance of alien strain (CF₁) mice to the progressive growth of lymphosarcoma 6C3H-ED (originating in C3H mice) is greatly impaired by intensive treatment with cortisone acetate. Seventeen of the 23 CF₁ mice which survived treatment with cortisone died of progressive growth of lymphosarcoma implanted from C3H mice, whereas only 2 of 37 untreated mice developed progressive tumors.

It should be pointed out that the course of cortisone dosage used to bring about the effects described were excessive, actually constituting a lethal concentration for some of the CF₁ mice. The nature of the change in resistance shown by these experiments has not been established, but it might be inferred that it is associated with the well known depression of normal lymphoid tissue and immune responses which large doses of cortisone induce.

Addendum. After the above manuscript was submitted for publication, a paper by E. L. Howes (Yale Jour. Biol. And Med. 1951, v23, 454) came to our attention. This paper described the progressive growth of adenocarcinoma EO771 or 775 when transplanted in Rockland Swiss mice treated with cortisone.