Abstract
Summary
Ethionine induces necrosis of the distal portion of the proximal convolutions in the rat kidney. On a normal diet renal involvement is seen more frequently and to a greater extent in male animals. A protein depletion diet increases very markedly the susceptibility of the kidney to the nephrotoxic action of ethionine in male and female rats. Methionine inhibits the renal toxicity of ethionine while glycine and alanine are without effect.
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