Abstract
Summary
1. Tissue slices from various human cancer and control tissues and mouse breast cancer were incubated in TTC solution with and without the enzyme inhibitors: fluoride, malonate and azide and the ^g of TTC reduced/mg of acetone dried tissues determined. 2. Both control and tumor tissues exhibited a linear relationship between the endogenous and fluoride inhibited TTC reduction. The tumors were characterized by a decreased fluoride inhibition as compared to homologous controls. Malonate inhibition of tumor tissue also tended to be minimal. The findings were discussed in terms of the metabolism of tumor tissue.
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