Abstract
Summary
(1) Of 100 human neoplasms implanted subcutaneously in X-irradiated rats and mice as sieved or minced cell suspensions, 33 had no mitotic cells at the end of the first generation (8 days), 34 showed cellular proliferation at the end of the first generation but could not be transferred successfully to a second, and 33 were transplanted for 2 generations or more with evidence of active growth and vascularization. (2) Epidermoid carcinomas were most successfully propagated. (3) Failures were in part due to infection and to delay between surgical removal of the tumor and its implantation in the heterologous hosts.
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