Abstract
Summary
Ephedrine in therapeutic doses (35 to 75 mg) administered intramuscularly to 7 subjects and intravenously to one failed to cause any consistent or significant change in renal plasma flow, filtration rate, PAH extraction ratio, or renal arterial—venous oxygen difference, despite an increase in mean blood pressure and pulse rate. These results are in agreement with the conclusion of Chasis, Goldring, and Smith(l) that, in marked contrast to adrenaline, ephedrine in therapeutic doses has no or a negligible effect on the renal circulation.
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