Abstract
Summary
1. The influence of colchicine on arrest of erythroid mitoses of intact rat marrow was measured quantitatively. 2. A comparison was made after colchicine injection of the erythroid mitotic percentage of normal rats and of those of erythropoietically stimulated animals. Fourteen normal rats showed a range of 2.5 to 4.8%, average 3.6%. Fifteen rats, 1 to 3 days after moderate hemorrhage, gave 3.8 to 12.0%, average 6.9%. Six rats exposed for 6 hours per day for 2 to 3 days (12 to 18 hours) to a barometric pressure of 300 mm Hg yielded 5.6 to 8.5%, average 7.0%. Mitotic percentage increase above normal was evident in the stimulated animals before an established reticulocyte response was observed.
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