Abstract
Summary
1. A comparative assay of the pituitary ACTH content of normal and thy—roidectomized rats was carried out by means of the adrenal ascorbic acid depletion method in hypophysectomized rats. 2. No significant difference was found between the ACTH stores of the normal and the thyroidectomy—pituitaries. 3. Since the hypophyses of thy—roidectomized rats are extremely poor in acidophilic and beta—granular material, it is concluded that neither the granulation of the acidophils nor that of the beta cells can be the morphological equivalent of ACTH storage. 4. The nature of the defective secretion of ACTH in hypothyroidism is briefly discussed.
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