Effect of Vitamins E,B 12 and Folacin on CCL 4 Toxicity and Protein Utilization in Rats. ∗

Abstract

Summary

Vit. E and vit. B₁₂ can replace each other in promoting protein utilization and in protecting against acute carbon tetrachloride toxicity in young rats reared on 10% protein diets deficient in these factors. The vit. B₁₂ requirement for protection against CCl₄ is considerably higher than for growth. Folacin supplements, alone, had no effect, but, in the presence of vit. B₁₂ or vit. E, this factor markedly improved protein utilization and growth. L-Cystine protected against the acute toxicity but a synergism between cystine and vit. E was not noted.