Abstract
Summary
Swiss mice infected intracerebrally with the Lansing strain of poliomyelitis virus show a significantly decreased incubation period before onset of paralysis following intraperitoneal inoculation with pertussis vaccine, pertussis—diphtheria toxoid or diphtheria toxoid alone. The results obtained were based on a series of 20 experiments carried out by 2 technicians working independently and involving over 650 mice. Similar results were also obtained in 6 out of 7 other experiments in which infected mice were injected intravenously with Salmonella typhimurium vaccine. Evidence is presented that Salmonella typhimurium is apparently responsible for the previously reported enhancing effect of autolyzed brain tissue diluent.
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