Metabolism of Glycine. ∗

Abstract

Summary

The metabolism of glycine in mice has been studied after a single injection of glycine-2-C¹⁴ by following the specific activity of the uncombined glycine in plasma, liver and skeletal muscle, as well as the specific activity of the respiratory CO₂. The size of the dynamic pool of glycine was found to be 30 mg per 100 g of which 10 mg per 100 g was uncombined glycine; the turnover time of the glycine pool was 1.5 hours and the rate of turnover 20 mg per 100 g per hour. The amount of glycine oxidized to yield CO₂ in the breath was found to be approximately 10 times the amount of glycine ingested in the food.