Selective Inhibition of Adrenal and Thyroid Stimulating Effect of Amphenone B ∗ by Cortisone and Thyroxine

Abstract

Summary

Amphenone “B” induces a marked hypertrophy of both the thyroid and adrenal in the rat. Simultaneous administration of thyroxin and Amphenone “B” prevents the thyroid hypertrophy without reducing the adrenal enlargement. Combined cortisone and Amphenone “B” administration prevents the adrenal enlargement without altering the thyroid hypertrophy. Thus, Amphenone “B” exerts its adrenal and thyroid effect by acting through two distinct end—points in the anterior pituitary.