Abstract
Summary
1. Nerve homogenates, but not those of muscle or liver, inhibit brain glycolysis, the inhibition being a linear function of the amount of nerve. 2. Two thirds of the inhibitor activity is in a protein and lipid fraction precipitated at pH 5.3 to pH 5.5. From 200 mg of fresh nerve, 3 mg of protein and a like amount of lipid are obtained. Even this semi—purified fraction loses activity slowly in the cold, almost at once on heating. 3. The inhibition is specific for brain hexokinase. The enzyme from yeast or liver is not inhibited; glycolysis of hexose phosphates by brain is not inhibited. Fructose loss is inhibited half as strongly as that of glucose. 4. Crystalline insulin can counteract the nerve inhibitor. This and its other properties are similar to those of the inhibitor from the anterior pituitary.
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