Abstract
Conclusions
The Lansing strain of poliomyelitis virus requires L-methionine for its growth and multiplication in cultures of human embryonic brain tissue. Its growth can be materially inhibited with DL-ethionine, a structural analogue of the essential amino acid. The inhibitor acts by interfering with the biosynthesis of the poliomyelitis virus just as it suppresses the growth of influenza virus. This technic affords a procedure for studying the growth requirements of poliomyelitis virus and for testing materials which may influence its growth.
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