Abstract
Summary
1. Rats fed aminopterin exhibit a concentration of liver ascorbic acid less than one-half normal, indicating that folic acid is probably involved in ascorbic acid synthesis in the rat. 2. Enzyme studies indicate that low ascorbic acid levels added in vitro reduce liver choline oxidase activity in the presence of homocysteine whereas higher levels stimulate activity of the enzyme system. Implications of this phenomenon with depression of choline oxidase activity by dietary aminopterin have been discussed.
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