Abstract
Summary
Semliki Forest virus multiplied in tissue cultures of certain normal and tumor tissues with maximum titers of 104.5 to 106.5 LD50 within 24 to 48 hours. SFV multiplied regularly to high titer in cultures of minced fibroma. Following intramuscular injection of the virus into rabbits bearing virus-induced fibromas, SFV caused rapid necrosis of the tumors. The effect was most apparent when SFV was inoculated simultaneously or within 2 days of the inoculation of fibroma virus. SFV did not multiply in cultures of normal adult rabbit tissue and caused no deaths or apparent illnesses in rabbits bearing fibromas.
Get full access to this article
View all access options for this article.