Abstract
Summary
1. The median lethal doses of podophyllin, podophyllotoxin, picropodophyllin, podophyllicacid, quercetin from podophyllin, quercetin from quercetron, podophyllotoxinized resin and colchicine were determined in adult mice. In this species podophyllin and podophyllotoxin respectively are approximately 1/15and 16 as toxic as colchicine. 2. A comparison of the median lethal doses of podophyllin and podophyllotoxinin young and adult rats demonstrated a greater degree of toxicity for young rats. 3. Cumulative toxic effects were produced in rats by administering podophyllin and podophyllotoxin multiple times a day in individual doses that were in the range of 1/6 and 1/5 of the LD50. 4. Observations on the symptomatology and/or pathologic alterations of rats poisoned with podophyllin, podophyllotoxin, podophyllic acid, picropodophyllin, quercetin and de-podophyllotoxinized resin and colchicine are presented. 5. In animals that succumbed to subcutaneous injections of colchicine there was an accumulation of arrested mitoses in the skin (positiv Dustin reaction); in animals killed by subcutaneous injections of podophyllin the Dustin reaction was negative as there were no epidermal changes.
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