Abstract
Summary
Administration of 4-amino-N-10 methyl-pteroylglutamic acid to rats caused reduction of food consumption, extracellular fluid volume, plasma volume and plasma concentrations of prcttei'n, calcium, and phosphorus. Plasma creatinine concentration was elevated. Starvation alone did not duplicate the effects of this compound. Increased urinary excretion of nitrogen and water did not occur. The loss of body water and plasma protein appears)to be the consequence of a previously described intestinal lesion produced by anti-folic acid agents. The relation between these biochemical changes and the meclhanism of lethal action remains obscure.
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