Abstract
Summary and Conclusions
The chemotherapeutic effect of a certain napthoquinonimine (compound Ro 2-3532/1) was studied on the peripheral infection of mice with Col-SK virus, F virus and EMC virus. It was found that a well tolerated single dose of 5 mg of the drug, administered intraperitoneally, was sufficient to protect a high percentage of the mice against infection with multiple paralytic doses of Col-SK or F virus injected simultaneously by the same route. Experiments in which the virus was injected intraperitoneally but the drug subcutaneously showed likewise a definite degree of protection though inferior to that observed when both were given by the same route. Significant protection could also be obtained up to and including 1 hour after intraperitoneal infection with small doses of virus. Experiments in which the drug was tested for its chemotherapeutic action against EMC virus showed only a minimum degree of protection considered to be insignificant. Some attempts were made to analyze the probable mode of action of the drug on Col-SK virus. It is concluded that protection occurs not because of cell-receptor blockade but that the virus is rendered non-infectious by some form of direct interaction between virus and drug.
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