Abstract
Summary
The oral administration of aureomycin or terramycin to man results in an extremely low concentration of fecal urobilinogen; a change which occurs during the first 48 to 72 hours of drug therapy, concurrently with other modifications in the character of the intestinal contents. Normal concentrations of urobilinogen may not be restored for so long as six or seven days following the discontinuance of drug administration. The depression of urobilinogen formation is probably the result of alterations in the flora of the intestine, which have not yet been completely defined. A case of hemolytic anemia is reported in which strikingly low fecal and urinary urobilinogen concentrations were observed while the patient was receiving aureomycin.
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