Abstract
Summary
Rat ACTH is a dose equivalent to 100 μg La-l-A per 100 g body weight, injected intravenously into rats, disappears rapidly from the circulating blood of intact and adrenalectomized rats. Five minutes after injection of the hormone into intact rats about 40% of the injected dose is present in extracellular fluid and 20% in the kidneys; after 15 minutes a negligible quantity is present in extracellular fluid and 15% in the kidneys. The adrenals have a relatively high concentration of the hormone although the concentration is lower than in the kidney. It is estimated that less than 1/500th and 1/2000th of the injected dose is present in the adrenals at 5 and 15 minutes after injection, respectively. Liver contains no detectable quantity of the injected ACTH either 5 or 15 minutes after injection of hormone. Injected ACTH could not be detected in the urine in these experiments.
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