Abstract
Summary
1. The xanthine oxidase factor of dietary liver has been investigated by feeding various liver fractions and residues to weanling rats and observing the response of the rat liver xanthine oxidase activity to the various fractions. 2. The results indicate that the unidentified factor is not extractable by methanol or ether but that it is retained in the extracted liver residue. Whole untreated liver gave a more significant response than any fraction or residue tested. 3. Dextrin in the place of sucrose in the diet with no liver or liver fraction added gave a response as great as that given by whole liver. 4. It appears that the increase in xanthine oxidase activity observed in the weanling rats fed liver or liver residue is possibly due to better biological value of the liver protein rather than to a trace factor in the liver.
The outhouse wish to thank Mr. R. J. Lalor and Mr. W. L. Leoschke of this department for furnishing us with samples of the methanol soluble liverfraction and the liver after methanol extraction.
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