Abstract
Summary
Intraperitoneal injection of fatal or near-fatal doses of alpha-naphthyl thiourea (ANTU) markedly lengthened gastric emptying time in rats, as determined by comparing the weights of stomach contents in ANTU-poisoned rats to those of controls. In some rats only minimal evacuation of the stomach had occurred after 24 hours. The chemical vagotomizing agent banthine, in sublethal doses, and epinephrine, in near fatal doses, also delayed gastric evacuation, although the effect of epinephrine wore off before that of ANTU. The explanation for this finding and its relation to other effects produced by ANTU are still unknown.
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