Abstract
Summary
1. The alpha, beta, gamma and delta isomers of benzene hexachloride are preferentially stored in the adipose tissue of rats and dogs. 2. Some storage of benzene hexachloride is found in kidneys, brain, liver and muscle tissue of rats. 3. Dogs show considerable storage of the alpha, beta and gamma isomers in the adrenals. 4. The degree of accumulation in the adipose tissue bears a direct relationship to the chronic toxicity of the isomers. 5. The relative rates of accumulation in rat adipose tissue show that the approximate maximum storage is accomplished within 6 weeks. 6. Upon removal of the benzene hexachloride diet, alpha, gamma and delta isomers disappear from rat fat depots within 3 weeks; the beta still persists in small amounts after 14 weeks.
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