Abstract
Summary
Seventeen rabbits were each given 16 intravenous injections of 10 cc/kg of one or another plasma substitute over a 2-month period. The solutions used were 6% dextran in distilled water, 3½% periston (polyvinylpyrrolidone) in distilled water, and 10% dextrose in physiological saline solution. No effects of treatment on behavior or body weight were noted. At autopsy, there was slight enlargement of the spleen, on the average about 70%, in the periston animals. Kidney and liver weights were not affected except for a possible slight increase in kidney weight with dextrose. On detailed microscopic examination, the one outstanding lesion was a foam cell storage of periston or some near derivative. Certain other and minor lesions were caused by periston and dextran, and none by dextrose.
Get full access to this article
View all access options for this article.