Abstract
Summary
(1) Octyl nitrite unlike glyceryl trinitrate is not effectively absorbed through the buccal membranes of the dog.(2) Octyl nitrite is a powerful depressor agent in the dog when administered by inhalation.(3) Intravenously in the dog the depressor potencies of octyl nitrite and glyceryl trinitrate are in the ratio of 1 to 1.34 on a molar basis, depending upon the nitrite and nitrate groups respectively present in each molecule. On an equal weight basis the depressor threshold for glyceryl trinitrate was found to be between one-fourth and one-tenth that of octyl nitrite.
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