Abstract
Summary
A metabolite of pamaquine hitherto undescribed has been obtained from the tissues and droppings of treated chickens. The in vitro antimalarial and methemoglobin-producing properties of this metabolite are approximately 16-fold those of pamaquine. There are striking similarities in ultraviolet absorption spectra and in vitro antimalarial and methemoglobin-inducing behavior of the ametabolite and the two 8-amino-5,6-quinoline-quinones studied.
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