In vitro Inhibition of Radiophosphate Uptake and Growth of a Neurotropic Virus by 5-Chlorouridine. ∗

Abstract

Summary

5-Chlorouridine inhibits the propagation of Theilers GD VII virus and the uptake of P³²0₄ by the ribonucleic acid fraction of minced, 1-day-old mouse brain but had no effects on other tissue fractions studied. Uridine partially reverses the inhibiting effects of 5-chlorouridine on virus propagation and on the uptake of P³²0₄ by the ribonucleic acid fraction. Virus propagation has been shown to be associated both with an increased turnover and increased net amount of ribonucleic acid phosphorus.