Thioglycollate Inactivation of Posterior Pituitary Antidiuretic Principle as Determined in the Rat. ∗

Abstract

Summary and Conclusions

After intraperitoneal or subcutaneous injection, an aqueous solution of sodium thioglycollate markedly reduces water diuresis in rats and cannot be used by either route to demonstrate unequivocally whether posterior pituitary antidiuretic principle has been inactivated. By the intravenous route in rats, thioglycollate does not interfere with diuresis and can be shown, as in the dog, to abolish the antidiuretic action of Pitressin. Therefore, there is no controlled experimental evidence that Pitressin contains more than one antidiuretic principle.