Abstract
Summary
A slight protection of guinea pigs treated with rutin and subjected to an LD50 dose of histamine has been confirmed. The failure of certain other investigators to substantiate this finding may have been due to excessive histamine dosage or the use of inadequately standardized animals. Quercitrin, quercetin and methyl hesperidin chalcone also were found to afford protection against histamine. The protection is slight and is of theoretical rather than clinical interest.
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