Abstract
The work of Carson and Campbell(l), which reported the fungistatic action of 3 antihistaminics, prompted an investigation concerning which the following is a preliminary report. In addition to testing fungistasis by several antihistaminics, we were also interested in determining whether the compounds are fungicidal as well. Lastly, it was considered of fundamental biochemical interest to determine whether the antifungal action of antihistaminics is based on interference with utilization of histamine (or a compound or compounds of similar structure) by the fungus.
The compounds studied were as follows: Benadryl. (Diphenhydramine HC1) Parke-Davis : Thephorin, (Phenindamine Tartrate) Hoffmann-La Roche; Thenylene, (Methapy-riline HC1) Abbott; Neo-Antergan, (Pyran-isamine Maleate) Merck; Pyribenzamine, (Tripelenamine EC1) Ciba, and Diatrine, (Metaphenilene HCI) Wm. R. Warner. The test culture employed was Trichophyton mentagrophytes (Emmons No. 640).
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