Toxicity of Colchicine,Di-isopropyl Fluorophosphate,Intocostrin,and Potassium Cyanide in Mice at 4°C

Abstract

Summary

The toxicity of colchicine, DFP, Intocostrin and KCN was increased in mice that were exposed to 4°C for 24 hours and maintained in the cold after injection. Animals that were acclimatized to the cold were no more susceptible to DFP than were controls treated at room temperature. The possible factors implicated in these findings are discussed.