Abstract
Summary
The participation of glycine in the biosynthesis of cytochrome c has been demonstrated. Under our conditions, the incorporation of C14 from glycine-2-C14 was of relatively very low order in the cytochrome c of heart and very high order in liver tissue which had undergone active regeneration. The data support the conclusion that in regenerating liver cytochrome c is fabricated in situ and not derived from other tissues. A rate of “turnover” for liver cytochrome c has been provisionally deduced, which is appreciably higher than the normal rate of hemoglobin “turnover.” It is tentatively proposed that chromoprotein biosynthesis is a general property of living, aerobic cells.
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