Abstract
Summary and Conclusions
1. The clearance of intravenously injected reduced glutathione from the blood of dogs is rapid (< 30 min.). 2. The disappearance of subcutaneously injected glutathione from the body of the mouse is much slower (> 3 hours). 3. The distribution of injected reduced glutathione is not uniform throughout the body. Of the organs studied it concentrates to a considerable extent in the liver, spleen, and kidneys.
4. These experiments suggest that concentration of glutathione at sites vital for survival may be the prime factor in glutathione protection of the irradiated mammal. Whether the protection arises from preventing radiation death of essential cells or whether the protection is mediated through protection of humoral factors essential to orderly hemopoiesis remains unanswered.
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