Succinate Stimulation of Normal and Tumor Tissue Slice Metabolism Measured by Reduction of Tetrazolium Chloride. ∗

Abstract

Summary

Studies were made of the endogenous and succinate stimulated in vitro reduction of TTC by tissue slices from various human normal and cancer tissues as well as liver, kidney and spleen slices of control and tumor bearing mice. The per cent stimulation by succinate was not found to differ significantly in normal and tumor tissues. These findings were compared with previous studies of oxidative stimulation by succinate. It was also found shown that the presence of a tumor did not change the endogenous or succinate stimulated dehydrogenase activity of the liver, kidney or spleen of mice as measured by the TTC technique.