Abstract
Summary
The technic of Potter(5) for measuring the effects of toxic agents on citrate accumulation in vivo was applied to studies on X-irradiation. Lethal doses of X-ray (800 r) markedly inhibited citrate accumulation in spleen, thymus, ileum, pancreas and testes of fluoroacetate-treated rats but exerted no significant effect on brain and heart. Sublethal doses of X-ray markedly inhibited citrate accumulation in spleen and thymus. The extent of inhibition was dependent upon the dose of X-ray and was reversible after sublethal doses and irreversible when lethal doses were given. Accumulation of citrate occurred in the livers of irradiated rats following fluoroacetate treatment in contrast to the inability of livers of normal male rats to accumulate citrate following fluoroacetate treatment.
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