Abstract
Summary
1. “Folic acid” deficiencies induced by aminopterin and by sulfa drugs in rats have been compared. 2. Aureomycin can counteract the toxic effects of 50, 75 and 100 μg of aminopterin/100 g of diet. The antibiotic is equally effective whether fed in the diet or given intraperitoneally. 3. Aureomycin is without effect on growth in rats made “folic acid deficient” on a sulfa diet. 4. Citrovorum factor concentrates are able to completely overcome the deficiency produced on either type of diet.
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