Abstract
Summary
A study has been made of the absorption and excretion of viomycin following intramuscular administration in humans. Maximum serum concentrations of 82 to 125 μg per ml were attained within 2 hours after a single dose of 25 to 50 mg per kilo. Reasonably high concentrations were achieved in the serum of patients receiving daily maintenance doses of the drug. Small concentrations of viomycin, 10 to 12.5 μg per ml, were detected in the cerebrospinal fluid in the presence of high serum concentrations of the drug, 100 to 125 |mUg per ml. Viomycin was excreted in the urine in high concentrations, and from 65 to 100% of the administered dose was recovered in the urine within 24 hours.
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