Abstract
Conclusion
1. The distribution and excretion of radioactive hafniurri181 sodium mandelate after its intravenous administration was studied in 17 rats sacrificed at intervals of 1, 2,3,4,8, and 16 days. 2. Seventy to 90% of the total activity was retained in the liver, spleen, the skeletal, muscular, and integumentary (pelt) systems. 3. Specific activities showed the spleen to be highest, followed by the liver, bone, and kidneys. 4. The adrenals, thyroid, pancreas, salivary glands, and testes showed a slight, but appreciable retention. 5. Hafnium in the blood was found chiefly (95 %) in the plasma and remained in appreciable amounts to 4 days. 6. Seven per cent of the total dose was excreted in 16 days with more being eliminated in the urine than in the feces, the urine/feces ratio being 2.4.
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