Abstract
Conclusions
(1) The anti-hyaluronidase titre of the blood of patients with lymphosarcoma, Hodgkin's Disease, and leukemia has been determined by means of the viscosi-metric method. (2) The anti-hyaluronidase titre is elevated in all 3 conditions and varies with the clinical condition of the patient. (3) Cortisone causes an exacerbation of the disease in myelocytic leukemia with a corresponding increase in the anti-hyaluronidase titre. (4) In lymphocytic leukemia and Hodgkin's disease, cortisone, ACTH and other forms of therapy cause a decrease in the anti-hyaluronidase titre corresponding with clinical improvement. (5) There is no apparent relationship between the degree of invasion of the blood stream and the bone mar-row picture and the changes in anti-hyaluronidase titre appears to be related to the quantity of tumor tissue rather than to its invasiveness.
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