Abstract
Summary
The experimental data indicate that Compound E markedly suppresses the pathological alterations of the Arthus reaction ordinarily produced in the rabbit by repeated injections of crystalline egg albumin. The adrenocorticotrophic hormone exerted a decidedly less marked effect. 2. Treatment with Compound E and ACTH produced atrophy of the lymphoid tissues, including the thymus and spleen, and a lymphocytopenia. These alterations were greater with Compound E and in addition, in the animals treated with this hormone, there were extensive deposition of glycogen and fat in the liver, a lipemia and focal necrosis of skeletal muscle. In the animals treated with Compound E the adrenals were small while in those treated with ACTH, the adrenals were enlarged but lacking in lipoid.
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