Abstract
Summary
In ovariectomized mice of strains with different mammary cancer incidence (C57. Dba, A), injected with equal amounts of alpha estradiol benzoate, the response of mammary gland, vagina and endometrium respectively varied in degree: Mice of strain C57 showed less mammary stimulation than mice of strains Dba or A. The vaginal epithelium was most sensitive in mice of strain C57, slower in responding in mice of strain Dba, and least responsive in mice of strain A. The endometrium reacted most vigorously in mice of strain C57, and less actively in strains Dba and A. Differences in the mammary cancer incidence of the strains examined are considered to be due to differences in tissue susceptibility rather than to genetic differences in the output of estrogen.
Get full access to this article
View all access options for this article.