Abstract
Summary
1. Lysozyme is produced in moderately large amounts by the gastrointestinal tract of dogs subjected to chronic stimulation with Mecholyl. The increase in lysozyme is demonstrable in the bloody diarrheal stools of intact animals and in material aspirated from isolated pouches of colon. 2. Cautery of canine rectum stimulates the local production of large amounts of lysozyme within 5 1/2 hours after injury. 3. The rapid production of lysozyme by injured bowel suggests that it is an early accompaniment of the inflammatory reaction and that its presence is a reflection rather than a cause of ulcerative alimentary disease.
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