Effects of Some Substituted Thioureas on Alpha-naphthylthiourea (ANTU) Toxicity to Rats

Abstract

Summary

1. l-ethyl-l-phenyl thiourea (EPTU) administered in an intraperitoneal dose of 50 mg/kg was effective in significantly reducing mortality and toxic symptoms in rats when given simultaneously with, one hour or 2 hours after two LD₅₀'s (5 mg/kg) of ANTU. All animals receiving EPTU survived. 2. Ethyl thiourea and n-butyl thiourea also conferred significant but less uniform protection when given in doses of 25 and 50 mg/kg.